Hydromorphone Wikipedia
Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Try to avoid driving or operating any heavy machinery while using hydromorphone because it is stronger than morphine and causes sedation. If side effects are mild, they may only last a short time. When used as directed crack cocaine: withdrawal symptoms timeline & detox treatment by a doctor, drugs in this class are relatively safe when taken as part of short-term therapeutic treatment. The problem is they are highly addictive and can be abused if they fall into the wrong hands. A capsule containing an extended-release formulation of hydrocodone is sold under the brand name Zohydro ER.
5 Dosage Modifications in Patients with Renal Impairment
- If you have questions about these drugs, talk with your healthcare provider.
- Caution is advised if you have diabetes, or any other condition that requires you to limit/avoid sugar in your diet.
- Divide the new total amount by the number of doses permitted based on dosing interval (e.g., 8 doses for every-three-hour dosing).
Note that this list is not all-inclusive and includes only common medications that may interact with Dilaudid. You should refer to the prescribing information for Dilaudid for a complete list of interactions. Avoid driving or operating machinery until you know how Dilaudid addiction and termination will affect you. Dizziness or severe drowsiness can cause falls or other accidents. Dangerous side effects or death can occur when alcohol is combined with hydromorphone. Do not stop using Dilaudid suddenly, or you could have unpleasant withdrawal symptoms.
Other Medical Problems
Also, if you have an abnormal heart rhythm, talk to your healthcare provider before using morphine. In most cases, generic forms of drugs cost less than brand-name products. Both drugs can cause severe side effects and can be addictive, so you should take them exactly as prescribed. Hydromorphone belongs to the group of medicines called narcotic analgesics (pain medicines).
Administration
Opioids have been shown to have a variety of effects on components of the immune system in in vitro and animal models. Overall, the effects of opioids appear to be modestly immunosuppressive. When discontinuing DILAUDID INJECTION in a physically-dependent patient, gradually taper the dosage [see DOSAGE AND ADMINISTRATION]. Do not abruptly discontinue DILAUDID INJECTION in these patients [see Drug Abuse And Dependence]. DILAUDID INJECTION is contraindicated in patients with known or suspected gastrointestinal obstruction, including paralytic ileus. Tolerance is a physiological state characterized by a reduced response to a drug after repeated administration (i.e., a higher dose of a drug is required to produce the same effect that was once obtained at a lower dose).
See also How to Use section for more information about addiction and how to properly measure the dose of the liquid. In an individual physically dependent on opioids, administration of the recommended usual dosage of the antagonist will precipitate an acute withdrawal syndrome. The severity of the withdrawal symptoms experienced will depend on the degree of physical dependence and the dose of the antagonist administered. If a decision is made to treat serious respiratory depression in the physically dependent patient, administration of the antagonist should be initiated with care and by titration with smaller than usual doses of the antagonist. Opioid-Induced Hyperalgesia (OIH) occurs when an opioid analgesic paradoxically causes an increase in pain, or an increase in sensitivity to pain. This condition differs from tolerance, which is the need for increasing doses of opioids to maintain a defined effect [see Dependence].
Never use Dilaudid in larger amounts, or for longer than prescribed. Swallow it whole to avoid exposure to a potentially fatal dose. There is inter-patient variability in the potency of opioid drugs and opioid formulations. Therefore, a conservative approach is advised when determining the total daily dosage of DILAUDID Oral Solution or DILAUDID Tablets. It is safer to underestimate a patient’s 24-hour DILAUDID dosage than to overestimate the 24-hour dosage and manage an adverse reaction due to overdose. Consider prescribing naloxone, based on the patient’s risk factors for overdose, such as concomitant use of CNS depressants, a history of opioid use disorder, or prior opioid overdose.
Hydromorphone belongs to a class of drugs known as opioid analgesics. It works in the brain to change how your body feels and responds to pain. When hydromorphone is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve the pain.
Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Also, lying down for a while may relieve dizziness or lightheadedness. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting. If you feel that the medicine is not working as well, do not use more than your prescribed dose. It is very important that your doctor check your progress while you are using this medicine.
In the geriatric population, age has no effect on the pharmacokinetics of hydromorphone. Only a small amount of the hydromorphone dose is excreted unchanged in the urine. Most of the dose is excreted as hydromorphone-3-glucuronide along with minor amounts of 6-hydroxy reduction metabolites. Hydromorphone is extensively metabolized via glucuronidation in the liver, with greater than 95% of the dose metabolized to hydromorphone-3-glucuronide along with minor amounts of 6-hydroxy reduction metabolites. At therapeutic plasma levels, hydromorphone is approximately 8-19% bound to plasma proteins. After an intravenous bolus dose, the steady state of volume of distribution [mean (%CV)] is 302.9 (32%) liters.
This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence). Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Drugs like hydromorphone and hydrocodone are habit-forming and have a high potential for addiction.
Instruct patients to inform their healthcare providers if they are taking, or plan to take serotonergic medications [see DRUG INTERACTIONS]. Assess each patient’s risk for opioid addiction, abuse, or misuse prior to prescribing DILAUDID INJECTION and monitor all patients receiving DILAUDID INJECTION for the development of these behaviors and conditions. Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression). The potential for these risks should not, however, prevent the proper management of pain in any given patient. Hydromorphone has a risk for abuse and addiction, which can lead to overdose and death. Hydromorphone may also cause severe, possibly fatal, breathing problems.
Hydromorphone injection is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. It belongs to the group of medicines watch out alcohol and anxiety called narcotic analgesics (pain medicines) and acts on the central nervous system (CNS) to relieve pain. Do not use this medicine for mild pain or pain that you only have once in a while or “as needed.”
